The Younger Laboratory
Engineering Scalable Cellular Systems and Technologies For Functional Precision Medicine
Genomic Medicine Center
Children's Mercy Research Institute
At Children's Mercy Kansas City

Functional Precision Medicine

A critical barrier in translational sciences is the lack of practical laboratory technologies with the capacity to inform evidence-based clinical treatments in a timely manner. For clinical indications with multiple therapeutic options that exhibit varied efficacy across individuals in the impacted patient population, the process of identifying the optimal therapeutic approach for any given individual can be a major bottleneck. The Younger laboratory has leveraged expertise in the generation of patient-derived cellular models and high-throughput cell-based screening to build a functional precision medicine platform that enables the rapid and accurate prediction of drug efficacy at single-patient resolution.

Patient-derived
Cellular Systems

Scalable iPSC
Reprogramming

Disease-relevant
Cellular Models

Efficient Organoid
Generation

Functional Profiling at Scale

High-throughput
Phenotypic Screening

Precision
Therapeutics

Patient-specific
Drug Screening



Sponsors of our Research and Development Programs:

Dr. Scott Younger, PhD

Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy Kansas City. Since joining Children's Mercy his laboratory has pioneered methods for the rapid, robust, and scalable production of patient-derived cellular models. The laboratory is currently focused on the development of platform-based approaches for functional precision medicine with an emphasis on reduction to practice and clinical implementation.

Dr. Younger came to Children's Mercy from the Broad Institute of MIT and Harvard where his group worked on the development of new methodologies to expand the utility of CRISPR-based genetic screens. Prior to working at the Broad Institute he completed his postdoctoral studies at Harvard University as an American Cancer Society Fellow. He holds a Ph.D. in cell and molecular biology from UT Southwestern Medical Center. He also received an M.S. in biotechnology from the University of Texas at San Antonio and a B.S.I. in bioinformatics from Baylor University.

Meet The Team

Scott Younger, PhDPrincipal Investigator
Associate Professor

John Means, PhDAssistant Director
Patient Cell Models

Teena Ramu, MSResearch Specialist

Sanchi VishwakarmaMedical Student


Recent Alumni

Jasmine McQuerry, PhD

Anabel Martinez-Bengochea, PhD

Contact Information

Scott Younger, PhD

2401 Gillham Rd / Rm 3902.12
Kansas City, MO 64108
styounger@cmh.edu
(816) 731-7221

Younger Laboratory

Children's Mercy Research Institute
Children's Mercy Kansas City
2401 Gillham Rd / Rm 3902.30
Kansas City, MO 64108