A critical barrier in translational sciences is the lack of practical laboratory technologies with the capacity to inform evidence-based clinical treatments in a timely manner. For clinical indications with multiple therapeutic options that exhibit varied efficacy across individuals in the impacted patient population, the process of identifying the optimal therapeutic approach for any given individual can be a major bottleneck. The Younger laboratory has leveraged expertise in the generation of patient-derived cellular models and high-throughput cell-based screening to build a functional precision medicine platform that enables the rapid and accurate prediction of drug efficacy at single-patient resolution.
Scalable iPSC
Reprogramming
Efficient Organoid
Generation
High-throughput
Phenotypic Screening
Patient-specific
Drug Screening
Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy Kansas City. Since joining Children's Mercy his laboratory has pioneered methods for the rapid, robust, and scalable production of patient-derived cellular models. The laboratory is currently focused on the development of platform-based approaches for functional precision medicine with an emphasis on reduction to practice and clinical implementation.
Dr. Younger came to Children's Mercy from the Broad Institute of MIT and Harvard where his group worked on the development of new methodologies to expand the utility of CRISPR-based genetic screens. Prior to working at the Broad Institute he completed his postdoctoral studies at Harvard University as an American Cancer Society Fellow. He holds a Ph.D. in cell and molecular biology from UT Southwestern Medical Center. He also received an M.S. in biotechnology from the University of Texas at San Antonio and a B.S.I. in bioinformatics from Baylor University.
2401 Gillham Rd / Rm 3902.12
Kansas City, MO 64108
styounger@cmh.edu
(816) 731-7221
Children's Mercy Research Institute
Children's Mercy Kansas City
2401 Gillham Rd / Rm 3902.30
Kansas City, MO 64108